Side effects: In a study of bloodroot as adjunctive therapy for HIV, patients were unable to tolerate doses over 5 mg, due to nausea and vomiting, dizziness and vertigo and angioedema.(19) The mouthwash containing sanguinarine can cause a burning sensation of the gums.(20)


Precautions/contraindications: Bloodroot is contraindicated in pregnancy, because it can stimulate uterine contractions.(18) People with gastrointestinal inflammatory diseases and glaucoma should avoid bloodroot.(2)

Adverse events: Fresh bloodroot can cause irritation of the skin and contact dermatitis. Contact with the eyes should be avoided.(18)