Interactions with pharmaceuticals: none known.
If ingested, bloodroot may result in a positive urine screen for opiates as it contains non-pharmacological concentrations of opiate alkaloids.


Interactions with other herbs: Bloodroot should not be given with other herbs that cause gastric irritation, e.g., angelica, coffee, cola, black and red pepper, cinnamon, calamus, dandelion root, devil’s claw root, galangal root, gentian, ginger, goldenseal, guarana seeds, horseradish, ironweed, mate, mustard, tobacco, quassia, snakeroot, wormwood, and yarrow.(18)