Goldenseal (Hydrastis canadensis)
Interactions
with pharmaceuticals:
Currently, only theoretical interactions are listed. Research on goldenseal’s
inhibition of cytochrome P450 3A4 enzymes is inconclusive. Physicians
may wish to monitor the effects of drugs metabolized by this enzyme while
their patient is taking goldenseal (including lovastatin, ketoconazole,
itraconazole, fexofenadine, triazolam, etc.)
Interactions with other herbs: Avoid using
with other herbs that increase stomach acid secretion, including angelica,
coffee, cola, black and red pepper, cinnamon, calamus, dandelion root,
devil’s claw root, galangal root, gentian, ginger, guarana seeds,
horseradish, ironweed, mate, mustard, tobacco, quassia, snakeroot, wormwood,
and yarrow, among others.20
Interactions
with disease states:
Patients with acute gastrointestinal inflammation should avid goldenseal.20
Any herb with purported immunostimulating effects should be avoided by
those with any autoimmune or proinflammatory disorder, including rheumatoid
arthritis and asthma.